Hyalu Tox PDRN

KEY INGREDIENTS

  1. Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide40
  2. Salmon extract DNA
  3. Tranexamic acid
  4. High-purity 3MDa hyaluronic acid, Trehalose & Glutathion

Structure of ‘Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40′

‘Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40’ is developed as recombination of peptide called “MTD” (Macro-molecule Transmission Domain) that has function of skin and target cell permeation and, active protein of botulinum toxin called ‘Light Chain’.  ‘MTD’ applied to our ingredient originated and developed from botulinum toxin ‘Heavy Chain,’  which performs a cell-penetration function of botulinum toxin. 

COMPARISON OF BOTULINUM INGREDIENTS

Composition

Composition

Composition

Heavy chain : Nerve cell penetration
Light chain : Botulinum Efficacy Part
Hemagglutinin
Non-toxin Non-Hemagglutinin

Heavy chain : Nerve cell penetration
Light chain : Botulinum Efficacy Part

Light Chain + MTD
Botulinum Efficacy Part
Marco-molecule Transmission Domain
(Skin & Nerve cell penetration)
= Recombination of the Protein

Commercialization

Commercialization

Commercialization

1980

1995

2014

Example

Example

Example

BOTOX (Allergan, US)
MEDITOXIN (Meditox, Korea)
Not permitted to use in Cosmetic Product

XEOMIN (Merz, Germany)
Not permitted to use in Cosmetic Produc

BLOOM Planet LTD 
The First Botulinum Ingredient on ICID

Molecular weight

Molecular weight

Molecular weight

900KDa

150KDa

50KDa

Salmon extract DNA

BENEFITS AND MECHANISMS:

  1. Improving microcirculation via process called angiogenesis. PDRN causes increased expression of a growth factor called Vascular Endothelial Growth Factor (VEGF) needed for the growth of blood vessels. Blood vessels are the highway for oxygen and nutrients for cells to grow and repair.
  2. Anti-inflammatory effects on tissues. Inflammation generates free radicals which damages the cells. If these damaged cells are unable to repair themselves, the cells will be removed via apoptosis, our body’s natural repair system. Through multiple mechanisms and cytokines, PDRN has been shown to have an anti-inflammatory effect and even reduce scar formation.
  3. Improves skin texture and elasticity. Collagen synthesis is enhanced by fibroblast activation. This also results in treatment of fine lines in the skin.
  4. Tissue repair and wound healing. PDRN salvages DNA and RNA fragments from damaged cells to incorporate them into new DNA for normal cell proliferation and recovery .
  5. Protection from UV damage- UV rays from the sun cause damage to our DNA and this accelerates signs of aging. PDRN has been shown to enhance DNA repair and clearance of toxic by-products of UV-damaged cells .

WHY SALMON IS SAFE?

The PDRN/DNA is derived from Salmon germ cells (that’s science speak for Salmon sperm cells).
The PDRN/DNA is then subjected to a very rigorous purification process that removes any antigens or proteins that might cause immune or biocompatibility reactions. Salmon DNA is very similar to human DNA. As alluded to above, the rigorous purification that the salmon cells are subjected to removes any proteins that may cause immune reactions.

Tranexamic acid

The basic chemical structure is trans-4 aminomethylcyclohexanecarboxylic acid (trans-AMCHA). It inhibits the plasminogen activator by reversibly blocking the lysine binding sites on both plasminogen and plasmin, a molecule responsible for degradation of fibrin. Plasmin is also known to play a role in activation of complement, neutrophils and monocytes and its inhibition thus may also have an anti-inflammatory effect.

Studies have found that it can inhibit UV- induced melanin synthesis by “blocking the interaction between keratinocytes [aka skin cells] and melanocytes [aka, melanin-producing cells].

High-purity 3MDa hyaluronic acid, Trehalose & Glutathione

3D HA Medical Grade
This innovative concept is obtained through a unique process that enriches products with Hyaluronic Acid molecules of 3 different molecular weight ranges. Due to their nature, they penetrate different layers of the skin, giving birth to a 3D uniform structure in the skin: shorter chains penetrate deeper than longer ones, building up a homogeneous and effective system to restore inflamed or aged skin.

• Restoration and optimal hydration.
• Aging prevention.
• Healing properties.
• Natural barrier for the skin.
• Preventing aggressions and preserving the right nutrients.
• Immediately visible effects.
• Enhancement of skin brightness.
• Improvement in skin texture.
• Improvement in skin elasticity and tone.

Trehalose, Arginine, and Glutathione
Enhanced moisturizing by superior water adsorption capacity Enhanced skin elasticity through fibroblast cell activation and antioxidant function through increasing the stability of vitamin C and E

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